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Incidence rare; Thiamine can cause anaphylactic reaction (coughing; difficulty in swallowing, hives, itching of skin, swelling of face, lips, or eyelids, wheezing or difficulty in breathing) usually after large intravenous dose.
Pyridoxine in high doses taken for several months has caused severe sensory neuropathy, progressing from unstable gait and numb feet to numbness to clumsiness of hands.
Cyanocobalamin can cause anaphylactic reaction (skin rash, itching,wheezing) while incidence less frequent are diarrhea and itching of skin.
